Sk Gupta Biochemistry Pdf 29: Explore the Fascinating World of Biochemistry

Studies confirmed that functionalization with PEG [52], PEGylated poly-L-lysine (PLL) [151], poly(ε-caprolactone) [152], polyvinyl alcohol [3], Pluronic [153], amine [98], carboxyl, and dextran [79] groups largely decreases the toxicity and improves the biocompatibility of graphene. In vivo results revealed that only mild chronic inflammation emerged after the subcutaneous injection of GO-Pluronic hydrogel and no noticeable short-term toxicity was tested after the intravenous injection of GO-DEX [79, 154]. PEGylated GS did not induce appreciable toxicity in mice exposed to 20 mg/kg for 3 months, as evaluated by blood biochemistry and histological examinations, and showed relatively low retention in the RES [52, 155]. Coating GO with chitosan almost eliminated the haemolytic activity in blood [39]. Moreover, the PEG coating effectively alleviated GO-induced acute tissue injuries; decreased GO aggregation and retention in the liver, lungs, and spleen; and promoted the clearance of GO [81], GO-DEX [79], and fluorinated graphene oxide (FGO) [156].

Laboratory parameters including complete blood cell count and differential, biochemistry panel, blood gasses, microbiological (blood and urine culture) and viral tests were performed as indicated by local policies. C-reactive protein (CRP) and procalcitonin (PCT) were measured locally in serum by a nephelometric assay and a Kryptor assay, respectively.

Sk Gupta Biochemistry Pdf 29

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